Lee E. Eiden

The paper investigates the differential roles of PACAP and glutamate in parabrachial neurons in shaping pain and stress responses, showing distinct effects on injury-induced hypersensitivity and inflammation-induced pain.

This study identifies the BAC as a PACAPergic hub linking emotional and spatial networks in looming-threat learning and memory using a novel behavioral paradigm and chemogenetic approaches.

This study investigates the role of cAMP-dependent signaling pathways in cocaine-induced immediate-early gene expression in D1 medium-spiny neurons of the nucleus accumbens, identifying distinct pathways for Egr-1 and c-Fos induction.

The paper designs peptide-based PAC1 antagonists using molecular dynamics simulations and a cell-based assay, finding that some proposed small molecule antagonists lack activity while confirming the efficacy of PACAP(6-38) and M65.

The paper identifies a multimodal calyx-like synapse in the forebrain extended amygdala formed by glutamatergic afferents from the pontine Kolliker-Fuse nucleus that co-release multiple neurotransmitters and neuropeptides.

The paper maps kisspeptin (KP) fiber distribution and Kiss1r expression in rat and mouse brains, showing their involvement in sensorial processing and behavioral state control beyond reproductive functions.

The paper identifies seven distinct kisspeptin neuronal chemotypes in the mouse brain and shows gonadectomy alters their expression patterns.

The paper identifies a neural circuit involving the NLOT that links the SON-AVP system to neocortical regions, promoting social behavior under osmotic stress.

The paper shows that vasopressin increases PSD95 and GluA1 expression in limbic regions, enhancing synaptic strength, while having no effect in non-target regions.

This study shows that RapGEF2 is required for cAMP-dependent ERK activation and synaptic potentiation in hippocampus, linking it to context-dependent fear conditioning and cognitive processes.

The paper identifies constitutive and acute transcriptomic effects of PACAP deficiency in mice, revealing distinct mechanisms of neuropeptide action on physiological and behavioral responses.

The paper examines ACE2 expression in rat brain tissues, identifying its presence in astrocytes, pericytes, endothelial cells, and specific neuronal populations, suggesting potential neurological impacts of SARS-CoV-2 infection.

This study shows that early life stress alters microglial synaptic pruning of axon initial segments in rats, with stronger effects in females, leading to increased fear responses in adulthood.

The paper investigates the role of PACAP signaling in neuronal subpopulations by analyzing its distribution and effects on behavior and gene expression in mice.

This study identifies a novel cAMP-NCS-Rapgef2-ERK-Egr-1/Zif268 pathway in D1 dopamine receptor neurons of the nucleus accumbens that is essential for cocaine-induced locomotor sensitization and conditioned place preference.