Yarimar Carrasquillo

Differential utilization of PACAP and glutamate in parabrachial neurons shapes pain and stress

The paper investigates the differential roles of PACAP and glutamate in parabrachial neurons in shaping pain and stress responses, showing distinct effects on injury-induced hypersensitivity and inflammation-induced pain.

Predicting Pain Using a Data-Driven Agent-Based Model of the Bilateral Central Amygdala

The paper develops a 3D agent-based model of the bilateral central amygdala to predict pain outcomes by integrating neuronal data from CGRPR and PKCδ cells.

CGRP receptor-expressing neurons in the central amygdala contributes to injury-induced pain hypersensitivity

This study identifies CGRPR-expressing neurons in the central amygdala as key players in pain hypersensitivity, showing their role in both injury-induced and spontaneous pain responses.

Loss of Intracellular Fibroblast Growth Factor 14 (iFGF14) Increases the Excitability of Mature Hippocampal and Cortical Pyramidal Neurons

This study shows that loss of iFGF14 increases excitability of mature hippocampal and cortical pyramidal neurons by altering INaT voltage-dependence and action potential waveform.

Divergent changes in PBN excitability in a mouse model of neuropathic pain

The paper investigates changes in PBN neuron excitability in two mouse models of neuropathic pain and finds that increased excitability and enhanced GABAB-mediated inhibition contribute to chronic pain.

The parabrachial to central amygdala circuit is a key mediator of injury-induced pain sensitization

This study shows the PbN[->]CeA circuit contributes to injury-induced pain hypersensitivity but not baseline nociception in mice.

Bidirectional modulation of pain-related behaviors in the zona incerta

This study identifies an inhibitory neural circuit from CeA-PKCδ neurons to the zona incerta that bidirectionally modulates pain-related behaviors in mice.

A parabrachial-to-amygdala circuit that determines hemispheric lateralization of somatosensory processing

The paper identifies a parabrachial-to-amygdala circuit mediated by CGRP that drives hemispheric lateralization of visceral pain processing in mice.

4R-Tobacco-Cembranoid is a Positive Allosteric Modulator of the Alpha7 Nicotinic Acetylcholine Receptor that modulates inflammation-induced thermal hypersensitivity in mice

This study identifies 4R-Tobacco-Cembranoid as a positive allosteric modulator of 7nAChRs that reduces thermal hypersensitivity and inflammation in mice, with sex-specific effects.

Sex differences in pain-related behaviors and clinical progression of disease in mouse models of visceral pain

This study examines sex differences in visceral pain behaviors and disease progression in mouse models of acute and persistent colon inflammation, finding sex-specific responses and disease outcomes.

Cell-type specificity of neuronal excitability and morphology in the central amygdala

This study identifies cell-type-specific differences in excitability and morphology between PKCδ+ and Som+ neurons in the central amygdala and links these differences to behavioral changes in neuropathic pain.