Romaciclib, a CDK8/CDK19 inhibitor, can overcome venetoclax resistance through a combinatorial strategy
Urszula Pakulska, Marta Obacz, Jerzy Woźnicki, Katarzyna Wiklik, Samarpana Chakraborty, Marta Micek, Vakul Mohanty, Diego Coelho, Elżbieta Adamczyk, Aniela Gołas, Adrianna Moszyńska, Hui Zhang, Magdalena Cybulska, Ewelina Kaniuga, Zuzanna Sandowska-Markiewicz, , Milena M. Mazan
This study shows that romaciclib combined with venetoclax overcomes venetoclax resistance in AML through synergistic apoptosis induction and suppression of resistance pathways.
bioRxiv · Jan 15, 2026 · PreprintCancer Biology