WNT-driven chromosomal instability as a biomarker for PORCN inhibition
Diego Garcia-Lopez, Azedine Zoufir, Bárbara Hernando, Patricia G. Santamarı́a, Alice Cádiz, Hector De Galard Terraube, Laura Madrid, Amy E Cullen, Simon A. Woodcock, Ania Piskorz, Nicola Wallis, Jackie M. Walling, James D. Brenton, Florian M. Markowetz, Jason Yip, , Geoff Macintyre
This paper identifies a chromosomal instability (CIN) biomarker that predicts response to PORCN inhibitors in cancers, validated through in vitro models, cell lines, and patient data.
bioRxiv · Apr 15, 2026 · PreprintCancer Biology