Azedine Zoufir

WNT-driven chromosomal instability as a biomarker for PORCN inhibition

This paper identifies a chromosomal instability (CIN) biomarker that predicts response to PORCN inhibitors in cancers, validated through in vitro models, cell lines, and patient data.

Decoding Non-coding SNPs: Systems Genomics Modelling Dissects the Heterogeneity of IBD

The paper models the impact of non-coding SNPs on gene regulatory networks in IBD to stratify patients based on gene dysregulation and therapeutic response.

A systems genomics approach to uncover patient-specific pathogenic pathways in a complex disease

This paper introduces iSNP, a workflow to identify patient-specific pathogenic pathways in ulcerative colitis by integrating SNP profiles with regulatory networks.