Multi-stromal organoid co-cultures model pancreatic cancer and pancreatitis epithelial cell-fibroblast heterogeneity
Wenlong Li, Muntadher Jihad, Eloise G. Lloyd, Marta Zaccaria, Gianluca Mucciolo, Gideon Nsubuga, Alwin Koonan-Lonappan, Joaquín Araos Henríquez, Priscilla S.W. Cheng, Sneha Harish, Sally Mills, Paul M Johnson, Weike Luo, Alejandro Alonso Montero, Rebecca J. Brais, , Giulia Biffi
This study compares fibroblast heterogeneity in pancreatic cancer and pancreatitis using organoid co-cultures and identifies distinct stromal reprogramming in each condition.
Nature Cell Biology · Sep 2, 2026Peer-reviewedCancer Biology