Rat and rabbit whole embryo culture as a new approach method for unlabeled therapeutic antisense oligonucleotide hazard identification with no requirement for microinjection or assisted transfection
Sara M Bender, Sharon Chapman, Sreenivas Nannapaneni, Joel D. Parry, Joyce Rendemonti, Stanley Robinson, Bradley Spencer‐Dene, Dinesh Stanislaus
This paper shows that rat and rabbit whole embryo culture can identify developmental hazards of antisense oligonucleotides without microinjection or transfection, using mipomersen as a test case.
Nucleic Acid Therapeutics · May 4, 2026Peer-reviewedPharmacology & Toxicology