Feedback loops involving AMPK, ERK and TFEB in matrix detachment leads to non-genetic heterogeneity
Saurav Kumar, Sayoni Maiti, Diptanshu Banerjee, Kishore Hari, Mohit Kumar Jolly, Annapoorni Rangarajan
The paper identifies a feedback loop between AMPK, ERK, and TFEB in matrix-detached cancer cells that generates non-genetic heterogeneity, affecting autophagy and cell survival.
bioRxiv · May 13, 2026 · PreprintCancer Biology