Saurav Kumar

De novo design of selective kinase modulators

This study designs genetically encoded miniproteins to modulate FAK kinase activity, showing they can inhibit or activate FAK in vitro and in cells, and adapt them to target other kinases.

Feedback loops involving AMPK, ERK and TFEB in matrix detachment leads to non-genetic heterogeneity

The paper identifies a feedback loop between AMPK, ERK, and TFEB in matrix-detached cancer cells that generates non-genetic heterogeneity, affecting autophagy and cell survival.

Integrin-independent Tie2 activation using de novo designed proteins

This paper designs a de novo Tie2 binder that activates the Angiopoietin-Tie2 pathway without integrin engagement, showing improved therapeutic potential in a mouse model of ARDS.

Development of PROTACs for targeted degradation of oncogenic TRK fusions

This paper develops PROTACs to degrade oncogenic TRK fusions, showing improved efficacy compared to traditional inhibitors.

De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine

The paper designs de novo proteins called NeoNectins that specifically bind integrin α5β1, enhancing cell attachment and tissue integration in biomaterials.