Feedback loops involving AMPK, ERK and TFEB in matrix detachment leads to non-genetic heterogeneity
Saurav Kumar, Sayoni Maiti, Diptanshu Banerjee…·Annapoorni Rangarajan
The paper identifies a feedback loop between AMPK, ERK, and TFEB in matrix-detached cancer cells that generates non-genetic heterogeneity, affecting autophagy and cell survival.