Early NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight
Michaela Gregorová, Marianna Santopaolo, Lucy C. Garner, Rahma F. Hayati, Divya Diamond, Narayan Ramamurthy, Vi Thuy Tran, Nguyet Minh Nguyen, Kate J. Heesom, Nguyen Lam Vuong, Eben Jones, Mike Nsubuga, Curtis Luscombe, Hoa Thi My Vo, Chanh Quang Ho, , Laura Rivino
The paper identifies early T and NK-cell dysfunction in dengue patients that predicts severe disease, with obesity exacerbating these signatures.
Nature Communications · Jul 1, 2025Peer-reviewedImmunology