Kate J. Heesom

This study identifies copper as a key mediator in mutualistic interactions between Candida albicans and Staphylococcus aureus biofilms, showing non-reciprocal copper handling and therapeutic potential via copper nanoparticles.

This study identifies UCHL3 as a host factor that stabilizes subgenomic flaviviral RNA condensates, promoting virus replication through interferon-independent mechanisms.

The paper identifies neuronal and astrocytic membrane proteins dependent on Retromer for endosomal recycling, highlighting SNX27-Retromer's role in glutamate transporter trafficking.

The paper identifies a stress-induced process called motile ciliophagy in Tetrahymena thermophila, where cilia are internalized and degraded to recycle axonemal components for regeneration.

This study identifies SPATS2L as a mediator of growth and survival in RUNX1-mutant blast-phase CML through stress granule formation, suggesting it as a therapeutic target.

This study identifies FDXR upregulation as a prognostic marker and therapeutic target in HTLV-1-associated ATL, showing its link to disease severity and sensitivity to fluorouracil.

This study identifies TOE1 as a novel β-catenin interactor in myeloid cells that modulates Wnt signaling via LEF-1 and regulates proliferation through PAK2.

This study identifies HA and its receptors CD44/RHAMM as key drivers of obesity-related glomerulopathy, showing their role in renal inflammation, fibrosis, and dysfunction, and suggests they as therapeutic targets.

This study identifies the RAB32-LRMDA-Commander complex and shows its role in melanosome biogenesis and pigmentation, revealing the mechanism of oculocutaneous albinism type 7.

The paper investigates how DNAAF9 and ARL3 regulate the transport and activation of ciliary outer dynein arms by displacing Shulin from the ODA complex.

The paper identifies Retromer as a hub for RAB GTPase regulation through proximity proteomics and biochemical analysis.

This study shows that GMAP210 and Golgin-160 have distinct roles in maintaining Golgi structure, both necessary for efficient ECM secretion and modification.

The paper identifies early T and NK-cell dysfunction in dengue patients that predicts severe disease, with obesity exacerbating these signatures.

The paper identifies a new VPS29 isoform, VPS29C, which exhibits auto-inhibition limiting its association with Retriever and Retromer accessory proteins, revealing new complexity in Retromer function.

The paper uses quantitative proteomics to compare EV cargo between M1 and M2 macrophages, identifying 132 differentially expressed proteins and their functional roles in immune responses.

This study identifies RSS as a recyclinopathy caused by dysfunction in the Commander endosomal recycling pathway, linking it to multiple tissue malformations.

The paper uses a multiomic approach to study Retromer's role in lysosomal health in human neuroglioma cells, revealing proteomic and transcriptomic changes linked to neurodegeneration.

This study identifies LRFN2 as a new SNX27-dependent cargo that regulates AMPA receptor trafficking and synaptic function, revealing an indirect mechanism for SNX27's role in neurological conditions.

This study uses subtractive interaction proteomics to identify signaling pathways activated by the t(6;9)-DEK/CAN oncogene in AML, revealing potential therapeutic targets.