Improving oral dissolution kinetics of weakly basic vodobatinib via slurry conversion to an amorphous drug-polymer salt
Luke DeLion, Sophia R. Dasaro, Mojhdeh Baghbanbashi, Dmitry Zemlyanov, Kurt D. Ristroph
This paper improves the oral dissolution of vodobatinib by converting it into an amorphous drug-polymer salt using slurry conversion, achieving a 35-fold increase in dissolution rate.
bioRxiv · Jun 27, 2026 · PreprintBioengineering