Kurt D. Ristroph

This study identifies LAP-TLR2 signaling as a key driver of inflammatory pathology in Listeria monocytogenes gastroenteritis, showing its role in epithelial damage and neutrophil recruitment.

This study shows that DSPE-PEG fails to retain mAbs on LNPs in vivo, while a higher molecular weight PCL-b-PEG anchor maintains stability, highlighting the importance of anchoring strength for extrahepatic delivery.

This paper shows that mesophase spacing in liquid crystalline nanocarriers predicts hydrophilic payload release kinetics, linking material composition to functional performance.

This paper improves the oral dissolution of vodobatinib by converting it into an amorphous drug-polymer salt using slurry conversion, achieving a 35-fold increase in dissolution rate.

The paper investigates RNA post hoc loading into empty lipid nanoparticles using turbulent mixing and finds it occurs within 12 ms under optimal conditions.

This study examines how mixing techniques and ethanol removal affect lipid nanoparticle (LNP) physicochemical properties using SAXS and computational fluid dynamics.

The paper compares the effects of eleven mixing techniques on mRNA lipid nanoparticle physicochemistry and biological performance, finding significant differences in particle properties and performance across methods.