Sophia R. Dasaro

Liquid crystalline mesophase spacing as a quantitative predictor of release kinetics for co-loaded hydrophilic and hydrophobic payloads

This paper shows that mesophase spacing in liquid crystalline nanocarriers predicts hydrophilic payload release kinetics, linking material composition to functional performance.

Improving oral dissolution kinetics of weakly basic vodobatinib via slurry conversion to an amorphous drug-polymer salt

This paper improves the oral dissolution of vodobatinib by converting it into an amorphous drug-polymer salt using slurry conversion, achieving a 35-fold increase in dissolution rate.

RNA post hoc loading into empty lipid nanoparticles occurs on millisecond timescales during turbulent mixing

The paper investigates RNA post hoc loading into empty lipid nanoparticles using turbulent mixing and finds it occurs within 12 ms under optimal conditions.

Identifying differential effects from eleven mixing techniques on mRNA lipid nanoparticle physicochemistry and biological performance

The paper compares the effects of eleven mixing techniques on mRNA lipid nanoparticle physicochemistry and biological performance, finding significant differences in particle properties and performance across methods.