Integration of Imaging-based and Sequencing-based Spatial Omics Mapping on the Same Tissue Section via DBiTplus
Archibald Enninful, Zhaojun Zhang, Dmytro Klymyshyn, Matthew H. Ingalls, Mingyu Yang, Hailing Zong, Zhiliang Bai, Negin Farzad, Graham Su, Alev Baysoy, Jungmin Nam, Yao Lu, Shuozhen Bao, Siyan Deng, Nancy Ruonan Zhang, , Rong Fan
Thermostable RNaseH release of barcoded cDNA keeps sections intact for CODEX imaging, yielding same-section whole-transcriptome and protein maps plus CODEX-guided spot deconvolution in FFPE tissues.
Nature Methods · Jan 15, 2026Peer-reviewedSystems Biology✦ In-depth digest