Yao Lu

Spatial Glyco-Codes Define Human Liver Pathology and Progression

This study introduces spatial-GPT, a platform for spatial glycan, protein, and transcriptome profiling in human liver tissues, revealing glyco-codes that define disease states and progression.

Decoding Spatial Programs in Human Glioblastoma Through Surprisal Information-Theoretical Analysis

This paper uses surprisal information-theoretic analysis on spatial transcriptomic data from human glioblastoma to uncover hidden spatial programs and interactions not detected by standard methods.

Human Lymph Node Cellular Senescence Atlas Reveals Age-Dependent Alteration in Germinal Center B Cell Function and Niches

This study maps age-related cellular senescence in human lymph nodes, identifying senescence markers and spatial shifts in germinal center B cells.

Single-cell spatial multi-omics molecular pathology enabled by SuperFocus

SuperFocus integrates histopathology with single-cell spatial multi-omics data from spot-based measurements, improving accuracy by 28-73% over existing methods.

Integration of Imaging-based and Sequencing-based Spatial Omics Mapping on the Same Tissue Section via DBiTplus

Thermostable RNaseH release of barcoded cDNA keeps sections intact for CODEX imaging, yielding same-section whole-transcriptome and protein maps plus CODEX-guided spot deconvolution in FFPE tissues.

Evolutionarily divergent Mycobacterium tuberculosis CTP synthase filaments are under selective pressure

This study shows that Mycobacterium tuberculosis CTP synthase forms unique filaments that stabilize enzyme activity and resist inhibition, with mutations affecting filament formation under positive selection in clinical isolates.