Long-read sequencing of Mycobacterial tuberculosis is comparable to short-read sequencing for antimicrobial resistance prediction and epidemiological studies.
Matthew Colpus, Catriona S Baker, Eloïse Roghi, Hanh Nguyen Hong, Phu Phan Trieu, Do D. A. Thu, A. N. Hall, Philip William Fowler, Timothy M Walker, Ruan Spies, Hermione J. Webster, Jeremy Westhead, Hong Thi Cam Thai, Robert Turner, Tim Peto, , Derrick W. Crook
This study compares long-read and short-read sequencing for tuberculosis drug resistance and outbreak analysis, finding they are comparable with minimal differences in key clinical outputs.
bioRxiv · Apr 8, 2026 · PreprintMicrobiology