Author

Ruan Spies

University of OxfordORCID 0000-0002-1584-9141Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Assay:whole-genome sequencing· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Alexandra HalliD· 2 shared Catriona S. BakeriD· 2 shared Derrick W. CrookiD· 2 shared Hong Thi Cam ThaiiD· 2 shared Jeremy WestheadiD· 2 shared Matthew ColpusiD· 2 shared Philip William FowleriD· 2 shared Shaheed Vally OmariD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

Alexandra HallORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Long-read sequencing of Mycobacterial tuberculosis is comparable to short-read sequencing for antimicrobial resistance prediction and epidemiological studies.

Matthew Colpus, Catriona S Baker, Eloïse Roghi, Hanh Nguyen Hong, Phu Phan Trieu, Do D. A. Thu, A. N. Hall, Philip William Fowler, Timothy M Walker, Ruan Spies, Hermione J. Webster, Jeremy Westhead, Hong Thi Cam Thai, Robert Turner, Tim Peto, , Derrick W. Crook

This study compares long-read and short-read sequencing for tuberculosis drug resistance and outbreak analysis, finding they are comparable with minimal differences in key clinical outputs.

bioRxiv · Apr 8, 2026 · PreprintMicrobiology

Characterising the performance of an antibiotic resistance prediction tool, gnomonicus, using a diverse testset of 2,663 Mycobacterium tuberculosis samples

Jeremy Westhead, Catriona S. Baker, Marc J. Brouard, Matthew Colpus, Bede Constantinides, Alexandra Hall, Jeff Knaggs, Marcela Lopes Alves, Ruan Spies, Hieu Thai, Sarah Surrell, Kumeren N. Govender, Tim Peto, Derrick W. Crook, Shaheed Vally Omar, , Philip William Fowler

This paper evaluates the performance of the gnomonicus tool for predicting antibiotic resistance in Mycobacterium tuberculosis using a diverse testset of 2,663 samples and compares it to TB-Profiler.

Microbial Genomics · Dec 15, 2025Peer-reviewedMicrobiology