Dissecting the role of RNA-binding proteins in early herpes simplex virus 1 transcription using acute protein depletion
Niclas Barke, Sawinee Masser, Doerte Stalling, Emanuel Wyler, Robert P. Zinzen, Sabrina Schreiner, Jens B. Bosse, Markus Landthaler
The paper investigates the role of five RNA-binding proteins in HSV-1 transcription and their impact on viral replication, finding that SPT5 is essential for immediate-early gene expression while SFPQ has a different regulatory role.
bioRxiv · Feb 10, 2025 · PreprintMolecular Biology