Sabrina Schreiner

Intrinsic immunity against HAdV is achieved by a novel epigenetic silencing complex

This study identifies the HUSH complex as a host factor that restricts HAdV infection through epigenetic silencing, and shows HAdV proteins inhibit this complex to promote viral replication.

Dissecting the role of RNA-binding proteins in early herpes simplex virus 1 transcription using acute protein depletion

The paper investigates the role of five RNA-binding proteins in HSV-1 transcription and their impact on viral replication, finding that SPT5 is essential for immediate-early gene expression while SFPQ has a different regulatory role.

Human Adenovirus (HAdV) mediated inhibition of the tumor suppressor p53 is controlled by SUMOylation of the viral E2A/DBP protein

This study identifies SUMOylation of HAdV E2A/DBP as a mechanism to inhibit p53 activity and apoptosis, revealing a novel pathway for viral oncogenic potential.

Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling

This study identifies a novel function of MCPyV small T antigen in suppressing the type I interferon response by reducing IRF9 levels, impacting immune evasion and tumor progression.

Nanopore Guided Annotation of Transcriptome Architectures

The paper develops a novel method for high-resolution transcriptome annotation from Nanopore DRS data, demonstrating its effectiveness on both synthetic and real datasets, including a new annotation of human adenovirus type F 41.