Jens B. Bosse

This study identifies BMP's role in autophagosome-lysosome fusion by analyzing lysosomal proteomes and lipidomes in GNPTAB-deficient intestinal cells.

This study shows that phosphorylation-regulated condensation of the HCMV protein pp150 couples tegument assembly to membrane recruitment, supporting viral replication.

The paper investigates how specific mutations in the SARS-CoV-2 N/ORF9b gene affect host immune responses and infection outcomes using recombinant viruses.

This study identifies CAPRIN1's localization to MVB-like egress compartments in SARS-CoV-2 infection and shows its role in limiting cytopathic effects.

This study maps HSV-1 virion-wide protein interactions, revealing maturation-driven network remodeling and conserved organizational principles across herpesviruses.

This paper investigates how environmental conditions influence the structural assembly and cytotoxic function of the Staphylococcus aureus virulence peptide PSM1, revealing condition-dependent polymorphic structures and their role in host-cell interactions.

This study shows that the MHV-68 nuclear egress complex (NEC) is not essential for nuclear egress but mediates C-capsid specificity, allowing some capsids to exit the nucleus through alternative pathways.

The paper validates AlphaFold-predicted protein interactions using LUCIA, identifying 23 novel interactions and establishing an ipTM score threshold for confidence.

This study identifies BANF1 as a host factor essential for ASFV replication and reveals that A151R and MGF360-21R inhibit the IFN-I response, independent of BANF1.

This paper introduces a fast-track affinity purification workflow that skips buffer exchange, enabling direct nMS analysis and improving protein recovery for challenging proteins.

This study develops a CRISPR/Cas9-based 3D live cell imaging system to track KSHV episomes in real-time, revealing their spatiotemporal dynamics during infection.

The paper investigates the role of five RNA-binding proteins in HSV-1 transcription and their impact on viral replication, finding that SPT5 is essential for immediate-early gene expression while SFPQ has a different regulatory role.

The paper provides proteome-wide structure predictions for all human herpesviruses and identifies new protein families and potential functions through structural analysis.

The paper uses single-cell RNA-sequencing to study HSV-1 infection in human fibroblasts, identifying NRF2 activation as an antiviral response that reduces virus production.