Nucleolar buffering of lamina-associated heterochromatin restrains Progerin-induced ageing programs
Chiara Mungo, Cristiana Bersaglieri, Daniele Paganini, Dominik Baer, Raffaella Santoro
This study shows that the nucleolus buffers Progerin-induced ageing by sequestering lamina-associated domains, preserving heterochromatin integrity and preventing transcriptional ageing.
bioRxiv · Oct 1, 2026 · PreprintMolecular Biology