Cristiana Bersaglieri

This study shows that the nucleolus buffers Progerin-induced ageing by sequestering lamina-associated domains, preserving heterochromatin integrity and preventing transcriptional ageing.

This study shows that LBR and LAP2 tether heterochromatin to the nuclear periphery, and their loss disrupts genome homeostasis by repositioning heterochromatin and altering gene expression.

This study identifies NPM1 as a mediator of nucleolar association with NADs and shows its role in establishing repressive H3K9me2 chromatin states at these domains.

This study shows PRAMEL7 interacts with CUL2 to destabilize NuRD complex, promoting ground-state pluripotency in ESCs by reducing repressive chromatin regulation.

The paper identifies a novel RNA-based mechanism in prostate cancer where BAZ2A interacts with TOP2A and KDM1A to repress gene expression, distinct from its role in rRNA gene silencing.

The paper develops a method to map nucleolar-associated domains (NADs) and shows they have distinct repressive chromatin states compared to nuclear lamina interactions.

This study shows TIP5 maintains genome compartmentalization in ground-state pluripotent stem cells by preventing active chromatin from invading repressive domains.