Raffaella Santoro

This study shows that excess cell size drives senescence by altering mRNA homeostasis and reorganizing the genome, leading to the secretory phenotype and cell cycle arrest.

This study shows that the nucleolus buffers Progerin-induced ageing by sequestering lamina-associated domains, preserving heterochromatin integrity and preventing transcriptional ageing.

This study identifies TCF3::HLF's role in rewiring the 3D genome to drive leukemia by regulating MEF2C and altering hematopoietic stem cell gene expression.

This study shows that LBR and LAP2 tether heterochromatin to the nuclear periphery, and their loss disrupts genome homeostasis by repositioning heterochromatin and altering gene expression.

This paper introduces NoLMseq, a method to map nucleolar-associated domains (NADs) in single cells, revealing their heterogeneity and response to nucleolar stress.

This study shows that disrupting FOXA1 and FOXA2 disrupts oncogenic programs in both AR-positive and AR-negative prostate cancers.

This study shows that SETD2 promotes lipotoxic injury in cHFpEF by regulating SREBP1 and lipid metabolism, and its inhibition improves cardiac function.

This study identifies NPM1 as a mediator of nucleolar association with NADs and shows its role in establishing repressive H3K9me2 chromatin states at these domains.

This study shows PRAMEL7 interacts with CUL2 to destabilize NuRD complex, promoting ground-state pluripotency in ESCs by reducing repressive chromatin regulation.

The paper identifies a novel RNA-based mechanism in prostate cancer where BAZ2A interacts with TOP2A and KDM1A to repress gene expression, distinct from its role in rRNA gene silencing.

The paper identifies KLF4 as a key transcription factor modulating gene expression in Ago mutant mouse embryonic stem cells, revealing noncanonical AGO functions beyond miRNA regulation.

The paper develops a method to map nucleolar-associated domains (NADs) and shows they have distinct repressive chromatin states compared to nuclear lamina interactions.

This study shows BAZ2A's role in prostate cancer stem-like state transition through its interaction with H3K14ac and repression of tumor suppressor genes.

This study shows TIP5 maintains genome compartmentalization in ground-state pluripotent stem cells by preventing active chromatin from invading repressive domains.