Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs
Madelynn N. Whittaker, Lauren C. Testa, Dominique L. Brooks, Aidan Quigley, Hooda Said, Garima Dwivedi, Ishaan Jindal, Daphne Volpp, Ping Qü, Josh Zhiyong Wang, Michael A. Levine, Rebecca C. Ahrens‐Nicklas, Qiaoli Li, Kiran Musunuru, Mohamad‐Gabriel Alameh, , Xiao Wang
This study evaluates hybrid guide RNAs to improve the specificity and efficiency of adenine base editing therapies for genetic disorders.
bioRxiv · Apr 22, 2024 · PreprintMolecular Biology