Hooda Said

Correction of a recurrent pathogenic variant in methylmalonic acidemia using adenine base editing

This study corrects a common pathogenic variant in MMA using adenine base editing in hepatocytes, showing efficient in vitro editing with minimal off-target effects.

The type I IFN-IL-27 axis promotes mRNA vaccine-induced CD8+ T cell responses

This study shows that IL-27, induced by mRNA-LNP vaccines, enhances CD8+ T cell responses through type I IFN signaling, improving vaccine efficacy against pathogens and tumors.

Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs

This study evaluates hybrid guide RNAs to improve the specificity and efficiency of adenine base editing therapies for genetic disorders.