Early mitochondrial stress and metabolic imbalance lead to photoreceptor cell death in retinal degeneration
Ke Jiang, Anupam Kumar Mondal, Yogita K. Adlakha, Jessica Gumerson, Angel M. Aponte, Linn M. Gieser, Jung-Woong Kim, Alexis Boleda, Matthew J. Brooks, Jacob K. Nellissery, Donald A. Fox, Robert S. Balaban, Raúl Covián, Anand Swaroop
This study identifies early mitochondrial stress and metabolic imbalances as key drivers of photoreceptor cell death in retinal degeneration using a multi-omics approach in a mouse model.
bioRxiv · Oct 10, 2021 · PreprintNeuroscience