Anand Swaroop

This study provides a comprehensive multiomic analysis of non-glaucomatous human trabecular meshwork cells using data from multiple laboratories.

The paper identifies 78 genes associated with elevated intraocular pressure and primary open-angle glaucoma by analyzing chromatin dynamics and integrating GWAS variants with 3D chromatin landscapes.

This study identifies PRSS56 as a retinal factor promoting ocular axial growth and links it to myopia susceptibility through genetic and functional analyses.

The paper shows that glycolysis and lactate regulate histone H3K18 lactylation to control gene expression in retinal development and maturation.

This study shows reserpine improves photoreceptor function and preservation in a rhodopsin P23H rat model of RP, with greater benefits observed in female rats.

The paper identifies interactions between NRL and RNA-binding proteins, including R-loops in retinal photoreceptors, revealing new roles for NRL in transcription and gene regulation.

The paper identifies RNA editing sites in human retinal transcriptomes and links editing QTLs to retinal diseases.

This study identifies reserpine as a drug candidate that improves photoreceptor survival in retinal ciliopathies by restoring proteostasis and ciliogenesis.

The paper investigates harmonin expression and localization in human retinas to understand USH1C pathophysiology and potential gene therapy approaches.

This study identifies early mitochondrial stress and metabolic imbalances as key drivers of photoreceptor cell death in retinal degeneration using a multi-omics approach in a mouse model.

This study shows that GSK3 signaling regulates the genesis of displaced ganglion cells in the retina, with loss of GSK3 leading to increased numbers of these cells and altered axon projections.

The paper shows Neurog2 and Ascl1 genes regulate cortical progenitor differentiation and folding through Notch signaling in lissencephalic brains.

The paper identifies folliculin (FLCN) as a mediator of diabetic retinopathy through genetic association and gene expression analysis.

HiCRes estimates and predicts HiC library resolution using mathematical concepts applied to human and mouse datasets.

This study shows that AMPK regulates retinal metabolism and that its loss leads to photoreceptor and RPE cell degeneration.

The paper identifies genes regulated by NRL and CRX that control rod photoreceptor presynapse morphology and validates their function through knockdown and CRISPR/Cas9 approaches.

Comparing retinal organoid transcriptomes against human fetal and adult retina places each culture on a developmental scale; replacing all-trans retinoic acid with 9-cis retinal sped rod differentiation.