Anupam Kumar Mondal

Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa

This study shows reserpine improves photoreceptor function and preservation in a rhodopsin P23H rat model of RP, with greater benefits observed in female rats.

Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects

This study identifies reserpine as a drug candidate that improves photoreceptor survival in retinal ciliopathies by restoring proteostasis and ciliogenesis.

Early mitochondrial stress and metabolic imbalance lead to photoreceptor cell death in retinal degeneration

This study identifies early mitochondrial stress and metabolic imbalances as key drivers of photoreceptor cell death in retinal degeneration using a multi-omics approach in a mouse model.

NRL- and CRX-guided gene network modulates photoreceptor presynapse size and positioning during retinal development

The paper identifies genes regulated by NRL and CRX that control rod photoreceptor presynapse morphology and validates their function through knockdown and CRISPR/Cas9 approaches.