Matthew J. Brooks

The paper shows that glycolysis and lactate regulate histone H3K18 lactylation to control gene expression in retinal development and maturation.

This study identifies early mitochondrial stress and metabolic imbalances as key drivers of photoreceptor cell death in retinal degeneration using a multi-omics approach in a mouse model.

The paper shows Neurog2 and Ascl1 genes regulate cortical progenitor differentiation and folding through Notch signaling in lissencephalic brains.

The paper identifies genes regulated by NRL and CRX that control rod photoreceptor presynapse morphology and validates their function through knockdown and CRISPR/Cas9 approaches.

Comparing retinal organoid transcriptomes against human fetal and adult retina places each culture on a developmental scale; replacing all-trans retinoic acid with 9-cis retinal sped rod differentiation.