Altered lipid homeostasis underlies selective neurodegeneration in SNX14 deficiency
Yijing Zhou, Vanessa Sánchez, Peining Jimmy Xu, Marco Flores‐Méndez, Brianna Ciesielski, Donna Yoo, Hiab Teshome, W. Mike Henne, Tim O’Brien, Clementina Mesaros, Naiara Akizu
This study shows that SNX14 deficiency causes cerebellar neurodegeneration through lipid metabolism defects and identifies a unique lipid metabolite profile linking acylcarnitine accumulation to neuronal loss.
bioRxiv · Nov 30, 2022 · PreprintNeuroscience