Author

Peining Jimmy Xu

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Clementina MesarosiD· 3 shared Aaron Wu· 1 shared Aoife O’FarrelliD· 1 shared Arjun RajiD· 1 shared Brian P. GoldspieliD· 1 shared Brianna CiesielskiiD· 1 shared Clémence QueriaultiD· 1 shared Crystal S. ConniD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

Clementina MesarosORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly

Mikel D. Haggadone, Brian P. Goldspiel, Aoife O’Farrell, Nora T. Kiledjian, Montana Knight, Talia Smith, Elena Anderson, Víctor R. Vázquez Marrero, Mark A. Boyer, Peining Jimmy Xu, Michael Scaglione, Zachary M. Powers, Clémence Queriault, Aaron Wu, Qihua Yang, , Will Bailis

This study shows that environmental branched-chain amino acids regulate ASC translation and NLRP3 inflammasome assembly through mTOR-dependent translational bursting.

bioRxiv · Jan 20, 2026 · PreprintImmunology

Ketosis rescues frataxin deficiency and corrects disease phenotypes in an FRDA animal model

Yina Dong, Miniat W. Adeshina, Ryan Smith, Lucie Vanessa Ngaba, Jacob An, Olivia Seline, Jennifer Coulman, Shahd Al Haj Ali, Clementina Mesaros, Peining Jimmy Xu, David R. Lynch

This study shows that ketosis increases frataxin levels and improves disease symptoms in a Friedreich ataxia mouse model.

bioRxiv · Jan 14, 2026 · PreprintBiochemistry

Altered lipid homeostasis underlies selective neurodegeneration in SNX14 deficiency

Yijing Zhou, Vanessa Sánchez, Peining Jimmy Xu, Marco Flores‐Méndez, Brianna Ciesielski, Donna Yoo, Hiab Teshome, W. Mike Henne, Tim O’Brien, Clementina Mesaros, Naiara Akizu

This study shows that SNX14 deficiency causes cerebellar neurodegeneration through lipid metabolism defects and identifies a unique lipid metabolite profile linking acylcarnitine accumulation to neuronal loss.

bioRxiv · Nov 30, 2022 · PreprintNeuroscience