Author

Tim O’Brien

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Brianna CiesielskiiD· 1 shared Clementina MesarosiD· 1 shared Donna Yoo· 1 shared Hiab Teshome· 1 shared Marco Flores‐MéndeziD· 1 shared Naiara AkizuiD· 1 shared Peining Jimmy Xu· 1 shared Vanessa SáncheziD· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Brianna CiesielskiORCID

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1 paper

Recent·Most cited

Altered lipid homeostasis underlies selective neurodegeneration in SNX14 deficiency

Yijing Zhou, Vanessa Sánchez, Peining Jimmy Xu, Marco Flores‐Méndez, Brianna Ciesielski, Donna Yoo, Hiab Teshome, W. Mike Henne, Tim O’Brien, Clementina Mesaros, Naiara Akizu

This study shows that SNX14 deficiency causes cerebellar neurodegeneration through lipid metabolism defects and identifies a unique lipid metabolite profile linking acylcarnitine accumulation to neuronal loss.

bioRxiv · Nov 30, 2022 · PreprintNeuroscience