Investigating the neuroprotective effect of AAV-mediated β-synuclein overexpression in a transgenic model of synucleinopathy
Dorian Sargent, Dominique Bétemps, Matthieu Drouyer, Jérémy Verchère, Damien Gaillard, Jean-Noël Arsac, Latifa Lakhdar, Anna Salvetti, Thierry Baron
This study investigates whether β-synuclein overexpression via AAV can inhibit α-synuclein aggregation in a synucleinopathy model, but finds no delay in disease onset and reports specific β-synuclein aggregates in treated mice.
Scientific Reports · Nov 27, 2018Peer-reviewedNeuroscience