Ezh2-dependent epigenetic reprogramming controls a developmental switch between modes of gastric neuromuscular regulation
Sabriya A. Syed, Yujiro Hayashi, Jeong‐Heon Lee, Huihuang Yan, Andrea Lörincz, Peter R. Strege, Gabriella Bedekovicsne Gajdos, Srdjan Milosavljevic, Jinfu J. Nie, Jüri Johannes Rumessen, Simon J. Gibbons, Viktor József Horváth, Michael R. Bardsley, Doug D. Redelman, Sabine Klein, , Tamás Ördög
The paper shows Ezh2-mediated epigenetic repression drives the conversion of gastric interstitial cells of Cajal into fibroblast-like cells during development, with reversible effects upon Ezh2 inhibition.
bioRxiv · Dec 4, 2018 · PreprintMolecular Biology