Dieter Saur

The paper shows bacterial invasion and neutrophil immunosuppression drive adenoma progression in a porcine FAP model using single-cell RNA sequencing and spatial transcriptomics.

This study shows that MYC suppresses lysosomal protein degradation in pancreatic ductal adenocarcinoma, promoting immune evasion by altering amino acid availability and immune cell responses.

This study shows that different colorectal cancer genotypes create distinct microbial ecosystems and that microbiota dependence decreases as tumors progress.

This study uses an in ovo model to show that the CAM platform supports tumor-stroma coevolution in pancreatic cancer, preserving patient-specific features and enabling functional analysis of stromal interactions.

Cellpin imputes and denoises spatial transcriptomes using a variational autoencoder trained on single-cell RNA-seq, outperforming existing methods without requiring cross-modality alignment.

Phoenix predicts spatially resolved single-cell gene expression from histology, identifying new biomarkers and validating them across cancers and treatment regimens.

This paper generates cross-species single-cell atlases of pancreatic cancer to study progression, therapy response, and immune evasion across human and mouse models.

spongEffects identifies patient-specific ceRNA modules to provide insights into miRNA regulatory activity using gene expression data alone.

The paper shows Ezh2-mediated epigenetic repression drives the conversion of gastric interstitial cells of Cajal into fibroblast-like cells during development, with reversible effects upon Ezh2 inhibition.