Gianrico Farrugia

This study identifies maladaptive Piezo1 mechanotransduction as a driver of smooth muscle aging in the gut, showing it impairs contractility and contributes to gastrointestinal dysfunction.

This study identifies C1qa⁺ muscularis macrophages as regulators of enteric synaptic homeostasis and gastrointestinal motility through complement-dependent mechanisms.

This study performs a genome-wide association analysis of hemorrhoidal disease in 944,133 individuals, identifying 102 risk loci and linking them to vascular and tissue development pathways.

The paper shows Ezh2-mediated epigenetic repression drives the conversion of gastric interstitial cells of Cajal into fibroblast-like cells during development, with reversible effects upon Ezh2 inhibition.