Author

Douglas Smith

Mayo Clinic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetic & Genomic Medicine· 1 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:C. elegans· 1 Research Focus:differential expression· 1 Research Focus:ecology & biodiversity· 1 Assay:electronic health records· 1 Organism:human· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Jessica Spangler· 2 shared Lei ZhangiD· 2 shared Vasisht Tadigotla· 2 shared Yvonne Helbert· 2 shared Akhilesh PandeyiD· 1 shared Ethan O. PerlsteiniD· 1 shared Éva MoravaiD· 1 shared Frédéric Maxime VaziD· 1 shared

Activity by Year

2015-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

Jessica Spangler

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

DHDDS-related juvenile parkinsonism is caused by impaired lipid metabolism, glycosylation, and mitochondrial dysfunction, which can be rescued by NAD⁺ treatment.

Irena Josephina Johanna Muffels, Kristin A. Kantautas, Georgia MacDonald, Kishore Garapati, Raghavendra Rao Pasupuleti, Rory James Tinker, Rameen Shah, Mathura A. Thevandavakkam, Justin Donnelly, Ron Hrtska, Douglas Smith, Jan Bert van Klinken, Frédéric Maxime Vaz, Akhilesh Pandey, Ethan O. Perlstein, , Éva Morava

This study identifies mitochondrial dysfunction and metabolic impairments in DHDDS-related juvenile parkinsonism and shows that NMN treatment improves symptoms in patient-derived organoids and clinical cases.

medRxiv · Jun 5, 2026 · PreprintGenetic & Genomic Medicine

Cannabis microbiome sequencing reveals several mycotoxic fungi native to dispensary grade cannabis flowers

Kevin McKernan, Jessica Spangler, Lei Zhang, Vasisht Tadigotla, Yvonne Helbert, Theodore Foss, Douglas Smith

The paper sequences the microbiome of dispensary grade cannabis flowers and identifies mycotoxic fungi, highlighting limitations in current microbial testing regulations.

bioRxiv · Nov 6, 2015Microbiology

Single molecule sequencing of THCA synthase reveals copy number variation in modern drug-type Cannabis sativa L.

Kevin J McKernan, Yvonne Helbert, Vasisht Tadigotla, Stephen McLaughlin, Jessica Spangler, Lei Zhang, Douglas Smith

The paper uses single molecule sequencing to show copy number variation of THCA synthase in Cannabis sativa, suggesting a more nuanced view of chemotype prediction.

bioRxiv · Oct 8, 2015 · PreprintPlant Biology