PhysiologybioRxiv
Age-related structural and functional changes of the intracardiac nervous system
Eliza Sassu, Gavin Tumlinson, Dragana Stefanovska…·Luis Hortells
This study examines age-related changes in cardiac Schwann cells, parasympathetic nerve fibers, and M2R expression in mice, finding reduced SC density, fewer parasympathetic fibers, and lower M2R expression in aged hearts, which correlates with increased arrhythmia risk.