AAV-mediated Expression of a Novel Conformational Anti-Aggregated alpha-Synuclein Antibody Prolongs Survival in a Genetic Model of alpha-Synucleinopathies
Matthias J. Duechs, Dragica Blazevic, Philipp Rechtsteiner, Cynthia Hess Kenny, Thorsten Lamla, Sarah Hong Hui Low, Jimmy Savistchenko, Manuela Neumann, Ronald Melki, Tanja Schönberger, Birgit Stierstorfer, David Wyatt, Frederik H. Igney, Thomas Ciossek
This study shows that AAV-mediated delivery of a novel anti-aggregated alpha-synuclein antibody improves survival in a mouse model of alpha-synucleinopathies.
bioRxiv · Nov 30, 2022 · PreprintNeuroscience