Manuela Neumann

Distinct TAF15 amyloid filament folds define multiple subtypes of FTLD-TAF15

This study identifies distinct TAF15 amyloid filament structures in different FTLD-FET subtypes, leading to the renaming of the disease group as FTLD-TAF15.

Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing

This study identifies genetic risk factors for FTLD-TDP subtypes using whole-genome sequencing and meta-analysis across multiple cohorts.

TDP-43 toxic gain of function links ALS, FTD and Alzheimers Disease through splicing dysregulation

This study identifies TDP-43-driven splicing dysregulation as a common mechanism in ALS, FTD, and Alzheimer's disease, linking them through mis-spliced mRNAs like APP.

A multi-omics dataset for the analysis Frontotemporal Dementia genetic subtypes

The paper presents a multi-omics dataset for genetic subtypes of frontotemporal dementia to identify molecular mechanisms disrupted in the disease.

AAV-mediated Expression of a Novel Conformational Anti-Aggregated alpha-Synuclein Antibody Prolongs Survival in a Genetic Model of alpha-Synucleinopathies

This study shows that AAV-mediated delivery of a novel anti-aggregated alpha-synuclein antibody improves survival in a mouse model of alpha-synucleinopathies.

Genome-wide association study of autopsy-confirmed Multiple System Atrophy identifies common variants near ZIC1 and ZIC4

Highly efficient intercellular spreading of protein misfolding mediated by viral ligand - receptor interactions

The paper shows viral ligand-receptor interactions enhance the spread of protein misfolding via extracellular vesicles and direct cell contact.