Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies
Tetiana Serdiuk, Virginie Redeker, Jimmy Savistchenko, Sandesh Neupane, Walther Haenseler, Yanick Fleischmann, Viviane Reber, Sabrina Keller, Cinzia Tiberi, Ruxandra Bachmann-Gagescu, Matthias Gstaiger, Thomas Braun, Roland Riek, Steve Gentleman, Adriano Aguzzi, , Paola Picotti
This study identifies structural and functional differences in alpha-synuclein fibrils from Parkinson's disease, Dementia with Lewy Bodies, and Multiple System Atrophy, linking these differences to disease-specific cellular responses and potential therapeutic targets.
Molecular Systems Biology · Mar 11, 2026Peer-reviewedSystems Biology