The C3HeB/FeJ Kramnik mouse as a model to investigate the efficacy of therapeutic tuberculosis interventions
Markus Depfenhart, Drieke Van der Merwe, Suraj P. Parihar, Kobus Venter, Theunis Theodorus Cloete, Yolandy Lemmer, Anne Grobler
This study evaluates the C3HeB/FeJ Kramnik mouse model for TB research by testing a novel Pheroid(R) formulation and highlights limitations in macrophage pathology and B-cell activity.
bioRxiv · Sep 19, 2025 · PreprintMicrobiology