Trastuzumab deruxtecan combination strongly enhances responses and overcomes sotorasib resistance in KRASG12C-mutant NSCLC
Hilal Özakıncı, Bina Desai, Denise Kalos, Dung‐Tsa Chen, Menkara Henry, Hitendra Singh Solanki, Theresa A. Boyle, Humberto E. Trejo Bittar, Gina S. Nazario, Eric B. Haura, Andriy Marusyk, Bruna Pellini
This study shows that combining trastuzumab deruxtecan with sotorasib improves responses in KRASG12C-mutant NSCLC and overcomes resistance, but HER2 expression levels influence treatment effectiveness.
bioRxiv · Dec 17, 2024 · PreprintCancer Biology