Macrophage Antigen Presentation Is Unleashed by Pan-RAS Inhibition to Promote Antitumor Immunity
Jie Shen, Weini Li, Xin He, Lianjun Zhang, Huidi Shucheng, ChunBo Zeng, Mingtian Che, Wei Fan, Suda Jo, Heping Yang, Yuan Yu, Zakir Khan, Zhi Chen, DuoYao Cao
This paper shows that pan-RAS inhibition enhances macrophage antigen presentation, promoting antitumor immunity in RAS-wild-type tumors through epigenetic modulation of NLRC5.
bioRxiv · Feb 2, 2026 · PreprintImmunology