Myosin binding protein-C limits strain induced cross-bridge detachment in response to rapid stretch in cardiac and skeletal muscle
Nichlas M. Engels, Rachel Sadler, Michel N. Kuehn, Devin L. Nissen, Dylan L. Reichert, Marius Meinhold, Wolfgang Albrecht Linke, Weikang Ma, Anthony L. Hessel, Samantha P. Harris
This study shows that different MyBP-C paralogs have similar effects on cross-bridge cycling but distinct responses to rapid stretch, with MyBP-C limiting strain-induced detachment in fast-twitch muscles.
bioRxiv · Mar 5, 2026 · PreprintPhysiology