Wolfgang Albrecht Linke

This study shows that different MyBP-C paralogs have similar effects on cross-bridge cycling but distinct responses to rapid stretch, with MyBP-C limiting strain-induced detachment in fast-twitch muscles.

This study identifies skNAC as critical for maintaining cardiomyocyte integrity and preventing heart failure by regulating proteome homeostasis and metabolic adaptation during pathological hypertrophy.

This study examines how mavacamten affects skeletal muscle structure by reducing ON-state myosin heads and shortening thin filament length, similar to its effects in cardiac muscle.

This study shows that titin cleavage in mice causes concentric cardiac remodeling, diastolic dysfunction, and fibrosis by disrupting mechanical connectivity.

This study shows that ablating PALLD in adult hearts causes dilated cardiomyopathy with intercalated disc abnormalities and fibrosis, suggesting PALLD's essential role in cardiac function.