Massively Parallel Bead-Free Force Spectroscopy with Fluorescence
Adam B. Yasunaga, Ryan Riopel, David Bakker, Dyuti Raghu, Micah Yang, Isaac T. S. Li
This paper introduces Tether Force Spectroscopy (TFS), a bead-free single-molecule force spectroscopy method that enables high-throughput, high-resolution measurements of biomolecular conformational dynamics with internally calibrated forces.
Science Advances · Jun 5, 2026Peer-reviewedBiophysics