Isaac T. S. Li

Characterization of tri-culture alveolar-like organoids to study fibrotic lung diseases

This study develops a 3D tri-culture alveolar organoid model to investigate fibrotic lung disease responses to TGF-β and bleomycin, revealing distinct transcriptional changes and signaling pathways.

Massively Parallel Bead-Free Force Spectroscopy with Fluorescence

This paper introduces Tether Force Spectroscopy (TFS), a bead-free single-molecule force spectroscopy method that enables high-throughput, high-resolution measurements of biomolecular conformational dynamics with internally calibrated forces.

Super-resolved spatial organization of the nucleolar transcriptome

The paper uses super-resolution imaging and in situ sequencing to map RNA distribution within nucleolar subdomains, revealing distinct RNA populations and processing dynamics.

Mechanical signatures of nucleic acid knot topology

This study shows that molecular topology in single-stranded DNA leads to distinct mechanical behaviors, providing a way to identify and quantify nucleic acid knots.